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The antibody against BMP15 was raised in rabbit using the Recombinant Human Bone morphogenetic protein 15 protein (143-392AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against BMP15 was raised in rabbit using the Recombinant Human Bone morphogenetic protein 15 protein (143-392AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human skin tissue using BMP15 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using BMP15 Antibody at dilution of 1:1002
| Cat.No | ADC-45286A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BMP15 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Bone morphogenetic protein 15 protein (143-392AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95972 |
Uniprot Id
O95972
Target Species
Human
Target Name
BMP15
Target Full Name
Bone morphogenetic protein 15
Target Function
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Target Involvement
Ovarian dysgenesis 2 (ODG2); Premature ovarian failure 4 (POF4)
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family
Target Research Area
Developmental Biology
Target Synonyms
BMP 15; BMP-15; BMP15; BMP15_HUMAN; Bone morphogenetic protein 15; GDF 9B; GDF-9B; GDF9B; Growth/differentiation factor 9B; ODG2 ; POF4
Target Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure.
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