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The antibody against BPI was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 248-487 of human BPI (NP_001716.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against BPI was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 248-487 of human BPI (NP_001716.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09709A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BPI |
| Target Synonyms | rBPI; BPIFD1; BPI | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2, Jurkat, Mouse liver, Mouse thymus, SK-Hep1 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 248-487 of human BPI (NP_001716.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P17213 | Immunogen Sequence |
Uniprot Id
P17213
Target Species
Human
Target Name
BPI
Target Full Name
Bactericidal permeability-increasing protein
Target Function
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Target Subcellular Location
Secreted. Cytoplasmic granule membrane.
Target Protein Families
BPI/LBP/Plunc superfamily, BPI/LBP family
Target Tissue Specificity
Restricted to cells of the myeloid series.
Target Research Area
Immunology
Target Synonyms
Bactericidal permeability-increasing protein; Bactericidal/permeability increasing protein; BPI; BPI fold containing family D; member 1; BPI_HUMAN; BPIFD1; CAP 57; CAP57; rBPI; Recombinant BPI holoprotein; rBPI
Target Background
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms.
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