Rabbit anti-Human BRAT1 Polyclonal Antibody

Uniprot Id

Q6PJG6

Target Species

Human

Target Name

BRAT1

Target Full Name

BRCA1-associated ATM activator 1

Target Function

Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors.

Target Involvement

Rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL)

Target Subcellular Location

Nucleus. Cytoplasm.

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

BAAT 1; BAAT1; BRAT 1; brat1; BRAT1_HUMAN; BRCA1-associated ATM activator 1; BRCA1-associated protein required for ATM activation protein 1; BRCA1-associated protein required for ATM activation-1; C7orf27; chromosome 7 open reading frame 27 ; HEAT repeat containing protein C7orf27; MGC22916; RMFSL

Target Background

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.