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The antibody against BRD1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human BRD1 (NP_055392.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against BRD1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human BRD1 (NP_055392.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00889A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BRD1 |
| Target Synonyms | BRL; BRPF1; BRPF2; BRD1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Jurkat | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human BRD1 (NP_055392.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O95696 | Immunogen Sequence |
Uniprot Id
O95696
Target Species
Human
Target Name
BRD1
Target Full Name
Bromodomain-containing protein 1
Target Function
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation.
Target Subcellular Location
Nucleus. Chromosome.
Target Tissue Specificity
Highly expressed in testis.
Target Synonyms
BR140-like protein; BRD1; BRD1_HUMAN; BRL; Bromodomain and PHD finger-containing protein 2; Bromodomain containing 1; Bromodomain-containing protein 1; BRPF1; BRPF2; DKFZp686F0325
Target Background
This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants.
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