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The antibody against BST1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 29-293 of human BST1 (NP_004325.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against BST1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 29-293 of human BST1 (NP_004325.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-06720A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BST1 |
| Target Synonyms | CD157; cADPR2; BST1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse lung | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 29-293 of human BST1 (NP_004325.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q10588 | Immunogen Sequence |
Uniprot Id
Q10588
Target Species
Human
Target Name
BST1
Target Full Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Target Function
Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Target Protein Families
ADP-ribosyl cyclase family
Target Tissue Specificity
Widely expressed.
Target Synonyms
ADP ribosyl cyclase 2; ADP-ribosyl cyclase 2; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Bone marrow stromal antigen 1; Bone marrow stromal cell antigen 1; BST 1; BST-1; BST1; BST1_HUMAN; cADPr hydrolase 2; CD157; CD157 antigen; Cyclic ADP ribose hydrolase 2; Cyclic ADP-ribose hydrolase 2; NAD(+) nucleosidase; OTTHUMP00000217617
Target Background
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population.
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