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The antibody against BTC was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Probetacellulin. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against BTC was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Probetacellulin. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
Western Blot analysis of KB cells using Probetacellulin Polyclonal Antibody
Western Blot analysis of KB cells using Probetacellulin Polyclonal Antibody2
| Cat.No | ADC-36741A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BTC |
| Target Synonyms | BTCProbetacellulin [Cleaved into: Betacellulin antibody; BTC)] antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Probetacellulin. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P35070 |
Uniprot Id
P35070
Target Species
Human
Target Name
BTC
Target Full Name
Probetacellulin
Target Function
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Target Subcellular Location
[Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
Target Research Area
Signal Transduction
Target Synonyms
BTCProbetacellulin [Cleaved into: Betacellulin; BTC)]
Target Background
This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.
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