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The antibody against Butyrylcholinesterase was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 29-270 of human Butyrylcholinesterase (NP_000046.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against Butyrylcholinesterase was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 29-270 of human Butyrylcholinesterase (NP_000046.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05549A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Butyrylcholinesterase |
| Target Synonyms | E1; CHE1; CHE2; BCHED; Butyrylcholinesterase | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, SW620 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 29-270 of human Butyrylcholinesterase (NP_000046.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P06276 | Immunogen Sequence |
Uniprot Id
P06276
Target Species
Human
Target Name
BCHE
Target Full Name
Cholinesterase
Target Function
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Target Involvement
Butyrylcholinesterase deficiency (BChE deficiency)
Target Subcellular Location
Secreted.
Target Protein Families
Type-B carboxylesterase/lipase family
Target Tissue Specificity
Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
Target Research Area
Neuroscience
Target Synonyms
Acylcholine acylhydrolase; BCHE; Butyrylcholine esterase; CHE1; CHE2; CHLE_HUMAN; Choline esterase II; Cholinesterase (serum) 2; Cholinesterase 1; Cholinesterase; E1; Pseudocholinesterase; Pseudocholinesterase E1
Target Background
This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine.
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