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The antibody against C16orf62 was raised in rabbit using the Recombinant Human UPF0505 protein C16orf62 protein (6-205AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against C16orf62 was raised in rabbit using the Recombinant Human UPF0505 protein C16orf62 protein (6-205AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
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Immunofluorescent analysis of HepG2 cells using C16orf62 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-11811A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | C16orf62 |
| Target Synonyms | antibody; Hypothetical protein LOC57020 antibody; MGC16824 antibody; UPF0505 protein C16orf62 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human UPF0505 protein C16orf62 protein (6-205AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7Z3J2 |
Uniprot Id
Q7Z3J2
Target Species
Human
Target Name
C16ORF62
Target Full Name
VPS35 endosomal protein-sorting factor-like
Target Function
Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability.; (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface.
Target Subcellular Location
Membrane; Single-pass membrane protein. Endosome.
Target Protein Families
UPF0505 family
Target Synonyms
C16orf62; Chromosome 16 open reading frame 62; CP062_HUMAN; DKFZp313M0539; DKFZp434B0212; Esophageal cancer associated protein; Esophageal cancer-associated protein; FLJ21040,; Hypothetical protein LOC57020; MGC16824; UPF0505 protein C16orf62
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