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The antibody against C8B was raised in rabbit using the Recombinant Human Complement component C8 beta chain protein (55-350AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against C8B was raised in rabbit using the Recombinant Human Complement component C8 beta chain protein (55-350AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human liver cancer using C8B Antibody at dilution of 1:1002
| Cat.No | ADC-16619A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | C8B |
| Target Synonyms | C8b antibody; CO8B_HUMAN antibody; Complement component 8 beta polypeptide antibody; Complement component 8 subunit beta antibody; Complement component C8 beta chain antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Complement component C8 beta chain protein (55-350AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P07358 |
Uniprot Id
P07358
Target Species
Human
Target Name
C8B
Target Full Name
Complement component C8 beta chain
Target Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Target Involvement
Complement component 8 deficiency, 2 (C8D2)
Target Subcellular Location
Secreted.
Target Protein Families
Complement C6/C7/C8/C9 family
Target Research Area
Cardiovascular
Target Synonyms
C8b; CO8B_HUMAN; Complement component 8 beta polypeptide; Complement component 8 subunit beta; Complement component C8 beta chain
Target Background
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants.
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