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The antibody against CA5A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 39-305 of human CA5A (NP_001730.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against CA5A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 39-305 of human CA5A (NP_001730.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-05497A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CA5A |
| Target Synonyms | CA5; CAV; CAVA; CA5AD; GS1-21A4.1; CA5A | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 39-305 of human CA5A (NP_001730.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P35218 | Immunogen Sequence |
Uniprot Id
P35218
Target Species
Human
Target Name
CA5A
Target Full Name
Carbonic anhydrase 5A, mitochondrial
Target Function
Reversible hydration of carbon dioxide. Low activity.
Target Involvement
Hyperammonemia due to carbonic anhydrase VA deficiency (CA5AD)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Alpha-carbonic anhydrase family
Target Research Area
Metabolism
Target Synonyms
CA5A; CA5Carbonic anhydrase 5A; mitochondrial; EC 4.2.1.1; Carbonate dehydratase VA; Carbonic anhydrase VA; CA-VA
Target Background
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2.
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