Rabbit anti-Human CACNA1B Polyclonal Antibody

Uniprot Id

Q00975

Target Species

Human

Target Name

CACNA1B

Target Full Name

Voltage-dependent N-type calcium channel subunit alpha-1B

Target Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Target Involvement

Dystonia 23 (DYT23)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1B subfamily

Target Tissue Specificity

Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Expressed in the cerebral white matter, cortex, hippocampus, basal ganglia, and cerebellum.

Target Synonyms

BIII; CACNN; DYT23; Cav2.2; NEDNEH; CACNL1A5; CACNA1B

Target Background

The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene.