Name: Rabbit anti-Human CACNA1C Polyclonal Antibody
SKU: ADC-08272A
Availability: InStock

Rabbit anti-Human CACNA1C Polyclonal Antibody

The antibody against CACNA1C was raised in rabbit using the Recombinant Human Voltage-dependent L-type calcium channel subunit alpha-1C protein (1755-1971AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.

ADC-08272A

$299.00

Number

Cat.No

ADC-08272A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CACNA1C

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Application

ELISA, IF, IHC

Storage

Upon receipt

Immunogen Description

Recombinant Human Voltage-dependent L-type calcium channel subunit alpha-1C protein (1755-1971AA)

Target Species

Human

Immunogen Sequence

Complete sequences for the immunogen, target protein, and peptides are available upon request.

Uniprot ID

Q13936

Background Information

Uniprot Id

Q13936
Target Species

Human
Target Name

CACNA1C
Target Full Name

Voltage-dependent L-type calcium channel subunit alpha-1C
Target Function

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).; (Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues.
Target Involvement

Timothy syndrome (TS); Brugada syndrome 3 (BRGDA3)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Perikaryon. Cell junction, synapse, postsynaptic density membrane. Cell projection, dendrite. Cell membrane, sarcolemma, T-tubule.
Target Protein Families

Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1C subfamily
Target Tissue Specificity

Detected throughout the brain, including hippocampus, cerebellum and amygdala, throughout the heart and vascular system, including ductus arteriosus, in urinary bladder, and in retina and sclera in the eye. Expressed in brain, heart, jejunum, ovary, pancr
Target Synonyms

alpha-1 polypeptide; cardiac muscle; isoform 1; L type; CAC1C_HUMAN; CACH 2; CACH2; CACN 2; CACN2; CACNA1C; CACNL1A1; Calcium channel; Calcium channel cardic dihydropyridine sensitive alpha 1 subunit; Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle; Calcium channel voltage dependent L type alpha 1C subunit; CaV1.2; CCHL1A1; DHPR alpha 1; DHPR alpha 1 subunit; LQT8; TS; Voltage dependent L type calcium channel alpha 1C subunit; Voltage dependent L type calcium channel subunit alpha 1C; Voltage gated calcium channel alpha subunit Cav1.2; Voltage gated calcium channel subunit alpha Cav1.2; Voltage gated L type calcium channel Cav1.2 alpha 1 subunit; splice variant 10*; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2

Rabbit anti-Human CACNA1C Polyclonal Antibody

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Immunogen Information

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