Rabbit anti-Human CACNA1E Polyclonal Antibody

Uniprot Id

Q15878

Target Species

Human

Target Name

CACNA1E

Target Full Name

Voltage-dependent R-type calcium channel subunit alpha-1E

Target Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1E subfamily

Target Tissue Specificity

Expressed in neuronal tissues and in kidney.

Target Synonyms

alpha-1 polypeptide; BII; Brain calcium channel II; CAC 1E; CAC1E; CAC1E_HUMAN; CACH 6; CACH6; CACNA1E; Cacnl1 a6; CACNL1A6; Calcium channel; Calcium channel; L type; alpha 1 polypeptide; isoform 6; calcium channel; R type; Cav 2.3; Cchra 1; Cchra1; isoform 6; L type; Voltage dependent R type calcium channel subunit alpha 1E; Voltage gated calcium channel subunit alpha Cav2.3; Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-gated calcium channel subunit alpha Cav2.3

Target Background

Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.