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The antibody against CACNA1I was raised in rabbit using the Synthetic Peptide as the immunogen. This antibody exists as a non-conjugated antibody. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against CACNA1I was raised in rabbit using the Synthetic Peptide as the immunogen. This antibody exists as a non-conjugated antibody. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen. This antibody has been validated on IHC, ELISA.
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Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using Cav3.3Rabbit pAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Mouse Brain Tissue using Cav3.3Rabbit pAb diluted at 1:200.2
| Cat.No | ADC-11304A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CACNA1I |
| Target Synonyms | CACNA1I antibody; KIAA1120 antibody; Voltage-dependent T-type calcium channel subunit alpha-1I antibody; Voltage-gated calcium channel subunit alpha Cav3.3 antibody; Ca(v)3.3 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthetic Peptide | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9P0X4 |
Uniprot Id
Q9P0X4
Target Species
Human
Target Name
CACNA1I
Target Full Name
Voltage-dependent T-type calcium channel subunit alpha-1I
Target Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H.
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1I subfamily
Target Tissue Specificity
Brain specific.
Target Synonyms
CACNA1I; KIAA1120; Voltage-dependent T-type calcium channel subunit alpha-1I; Voltage-gated calcium channel subunit alpha Cav3.3; Ca(v)3.3
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