Rabbit anti-Human CACNA2D4 Polyclonal Antibody

Uniprot Id

Q7Z3S7

Target Species

Human

Target Name

CACNA2D4

Target Full Name

Voltage-dependent calcium channel subunit alpha-2/delta-4

Target Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.

Target Involvement

Retinal cone dystrophy 4 (RCD4)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Calcium channel subunit alpha-2/delta family

Target Tissue Specificity

Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophils of the pi

Target Synonyms

CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4; Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4]

Target Background

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.