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The antibody against CACNB1 was raised in rabbit using the Recombinant Human Voltage-dependent L-type calcium channel subunit beta-1 protein (429-598AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against CACNB1 was raised in rabbit using the Recombinant Human Voltage-dependent L-type calcium channel subunit beta-1 protein (429-598AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human brain tissue using CACNB1 Antibody at dilution of 1:1002
| Cat.No | ADC-16808A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CACNB1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Voltage-dependent L-type calcium channel subunit beta-1 protein (429-598AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q02641 |
Uniprot Id
Q02641
Target Species
Human
Target Name
CACNB1
Target Full Name
Voltage-dependent L-type calcium channel subunit beta-1
Target Function
Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit.
Target Subcellular Location
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein.
Target Protein Families
Calcium channel beta subunit family
Target Tissue Specificity
Detected in heart ventricle (at protein level). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.
Target Synonyms
CAB1; CACB1_HUMAN; CACNB1; CACNLB1; Calcium channel L type beta 1 polypeptide; Calcium channel voltage dependent beta 1 subunit; Calcium channel voltage-dependent subunit beta 1; CCHLB1; Dihydropyridine sensitive L type calcium channel beta 1 subunit; MGC41896; Voltage dependent L type calcium channel beta 1 subunit; Voltage-dependent L-type calcium channel subunit beta-1
Target Background
The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
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