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The antibody against CACYBP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-228 of human CACYBP (NP_055227.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CACYBP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-228 of human CACYBP (NP_055227.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-13737A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CACYBP |
| Target Synonyms | SIP; GIG5; PNAS-107; S100A6BP; BP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-228 of human CACYBP (NP_055227.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9HB71 | Immunogen Sequence |
Uniprot Id
Q9HB71
Target Species
Human
Target Name
CACYBP
Target Full Name
Calcyclin-binding protein
Target Function
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Target Subcellular Location
Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
Target Synonyms
CacyBP; Calcyclin binding protein; Calcyclin-binding protein; CYBP_HUMAN; GIG 5; GIG5; Growth inhibiting gene 5; Growth inhibiting gene 5 protein; hCacyBP; MGC87971; PNAS 107; PNAS107; RP1 102G20.6; S100A6 binding protein; S100A6-binding protein; S100A6BP; Siah-interacting protein; SIP
Target Background
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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