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The antibody against CAD was raised in rabbit using the Synthesized peptide derived from Human CAD around the non-phosphorylation site of T456. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against CAD was raised in rabbit using the Synthesized peptide derived from Human CAD around the non-phosphorylation site of T456. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
$167.00
| Cat.No | ADC-33755A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CAD |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from Human CAD around the non-phosphorylation site of T456. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P27708 |
Uniprot Id
P27708
Target Species
Human
Target Name
CAD
Target Full Name
Multifunctional protein CAD
Target Function
This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Target Involvement
Epileptic encephalopathy, early infantile, 50 (EIEE50)
Target Subcellular Location
Cytoplasm. Nucleus. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
Target Protein Families
Metallo-dependent hydrolases superfamily, DHOase family, CAD subfamily
Target Research Area
Others
Target Synonyms
CAD; CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase; EC 6.3.5.5); Aspartate carbamoyltransferase; EC 2.1.3.2); Dihydroorotase; EC 3.5.2.3)]
Target Background
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.
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