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The antibody against CAD was raised in rabbit using the Peptide sequence around phosphorylation site of threonine 456 (P-I-T(p)-P-H) derived from Human CAD. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, IHC.
The antibody against CAD was raised in rabbit using the Peptide sequence around phosphorylation site of threonine 456 (P-I-T(p)-P-H) derived from Human CAD. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, IHC.
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Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using CAD (Phospho-Thr456) antibody (left)or the same antibody preincubated with blocking peptide (right).
| Cat.No | ADC-42697A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CAD |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Peptide sequence around phosphorylation site of threonine 456 (P-I-T(p)-P-H) derived from Human CAD. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P27708 |
Uniprot Id
P27708
Target Species
Human
Target Name
CAD
Target Full Name
Multifunctional protein CAD
Target Function
This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Target Involvement
Epileptic encephalopathy, early infantile, 50 (EIEE50)
Target Subcellular Location
Cytoplasm. Nucleus. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
Target Protein Families
Metallo-dependent hydrolases superfamily, DHOase family, CAD subfamily
Target Research Area
Others
Target Synonyms
CAD; CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase; EC 6.3.5.5); Aspartate carbamoyltransferase; EC 2.1.3.2); Dihydroorotase; EC 3.5.2.3)]
Target Background
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.
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