Rabbit anti-Human Cadherin-13 (CDH13) Monoclonal Antibody

Uniprot Id

P55290

Target Species

Human

Target Name

CDH13

Target Full Name

Cadherin-13

Target Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Target Tissue Specificity

Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.

Target Synonyms

CAD13_HUMAN; Cadherin-13; CDH13; CDHH; H-cadherin; Heart cadherin; P105; T cad; T Cadherin; T-cad; T-cadherin; Truncated cadherin

Target Background

This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.