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Rabbit anti-Human CALCRL Polyclonal Antibody

The antibody against CALCRL was raised in rabbit using the Synthetic peptide of Human CALCRL as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.

ADC-26863A

The antibody against CALCRL was raised in rabbit using the Synthetic peptide of Human CALCRL as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.

$299.00

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Specifications


Cat.No ADC-26863A ClonalityPolyclonal
Host SpeciesRabbitTarget NameCALCRL
Target SynonymsCALCRL; CGRPR; Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptorFormLiquid
Species ReactivityHumanIsotypeIgG
Storage Buffer0.05% NaN3, 40% Glycerol., pH7.4 PBSPurification MethodAntigen affinity purified
ConjugateNon-conjugatedApplicationELISA, IHC, WB
StorageUpon receipt

Immunogen Information


Immunogen DescriptionSynthetic peptide of Human CALCRLTarget SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDQ16602
Background Information
  • Uniprot Id

    Q16602

  • Target Species

    Human

  • Target Name

    CALCRL

  • Target Full Name

    Calcitonin gene-related peptide type 1 receptor

  • Target Function

    Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3. Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

  • Target Subcellular Location

    Cell membrane; Multi-pass membrane protein.

  • Target Protein Families

    G-protein coupled receptor 2 family

  • Target Tissue Specificity

    Predominantly expressed in the lung and heart.

  • Target Synonyms

    CALCRL; CGRPR; Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor

  • Target Background

    Enables adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in endoplasmic reticulum; endosome; and lysosome. Part of CGRP receptor complex and adrenomedullin receptor complex. Colocalizes with plasma membrane. Implicated in hereditary lymphedema.

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