Rabbit anti-Human CALU Polyclonal Antibody

Uniprot Id

O43852

Target Species

Human

Target Name

CALU

Target Full Name

Calumenin

Target Function

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity.

Target Subcellular Location

Endoplasmic reticulum membrane. Golgi apparatus. Secreted. Melanosome. Sarcoplasmic reticulum lumen.

Target Protein Families

CREC family

Target Tissue Specificity

Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

Target Synonyms

CALU; CALU_HUMAN; Calumenin 1; Calumenin 2; Calumenin; Crocalbin; crocalbin-like protein; FLJ90608; IEF SSP 9302; multiple EF-hand protein; OTTHUMP00000212712; OTTHUMP00000212713; OTTHUMP00000212714; OTTHUMP00000212715

Target Background

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.