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The antibody against CAMLG was raised in rabbit using the Recombinant Human Calcium signal-modulating cyclophilin ligand protein (1-189AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF, IP.
The antibody against CAMLG was raised in rabbit using the Recombinant Human Calcium signal-modulating cyclophilin ligand protein (1-189AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF, IP.
$299.00
Immunofluorescent analysis of HepG2 cells using CAMLG Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-09761A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CAMLG |
| Target Synonyms | CAMLG antibody; CAML antibody; Calcium signal-modulating cyclophilin ligand antibody; CAML antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB, IP |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Calcium signal-modulating cyclophilin ligand protein (1-189AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P49069 |
Uniprot Id
P49069
Target Species
Human
Target Name
CAMLG
Target Full Name
Guided entry of tail-anchored proteins factor CAMLG
Target Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Tissue Specificity
Ubiquitous. Highest levels in brain, testis and ovary.
Target Synonyms
CAMLG; CAML; Calcium signal-modulating cyclophilin ligand; CAML
Target Background
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
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