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The antibody against CAPG was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-348 of human CAPG (NP_001738.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against CAPG was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-348 of human CAPG (NP_001738.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-13158A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CAPG |
| Target Synonyms | MCP; AFCP; HEL-S-66; PG | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat heart, HL-60, Mouse lung, Mouse spleen, Rat lung, THP-1 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-348 of human CAPG (NP_001738.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P40121 | Immunogen Sequence |
Uniprot Id
P40121
Target Species
Human
Target Name
CAPG
Target Full Name
Macrophage-capping protein
Target Function
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
Target Subcellular Location
Nucleus. Cytoplasm. Melanosome. Cell projection, lamellipodium. Cell projection, ruffle.
Target Protein Families
Villin/gelsolin family
Target Tissue Specificity
Macrophages and macrophage-like cells.
Target Research Area
Immunology
Target Synonyms
Actin capping protein GCAP39; Actin regulatory protein CAP G; Actin regulatory protein CAP-G; AFCP; Capg; CAPG_HUMAN; Capping actin protein gelsolin like; Capping protein (actin filament) gelsolin like; Capping protein gelsolin like; Epididymis secretory protein Li 66; gCap39; Gelsolin like capping protein; HEL S 66; Macrophage capping protein; Macrophage-capping protein; mbh1; MCP; Myc basic motif homolog 1
Target Background
This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene.
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