Rabbit anti-Human CAPN10 Polyclonal Antibody

Uniprot Id

Q9HC96

Target Species

Human

Target Name

CAPN10

Target Full Name

Calpain-10

Target Function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

Target Involvement

Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1)

Target Protein Families

Peptidase C2 family

Target Tissue Specificity

Detected in primary skeletal muscle cells (at protein level). Ubiquitous.

Target Synonyms

Calcium activated neutral protease ; Calcium activated neutral proteinase 10; Calcium-activated neutral proteinase 10; calpain like protease CAPN10; Calpain-10; Calpain10; CAN10_HUMAN; CANP 10; CANP10; CAPN 10; CAPN10; EC 3.4.22.; KIAA1845; NIDDM1

Target Background

Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.