Rabbit anti-Human CAPN3 Polyclonal Antibody

The antibody against CAPN3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 70-309 of human CAPN3 (NP_775111.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-04470A

Number

Cat.No	ADA-04470A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CAPN3
Target Synonyms	p94; CANP3; LGMD2; nCL-1; CANPL3; LGMD2A; LGMDD4; LGMDR1; CAPN3	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Mouse skeletal muscle, Rat skeletal muscle, THP-1	Application	ELISA, WB

Cat.No

ADA-04470A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CAPN3

Target Synonyms

p94; CANP3; LGMD2; nCL-1; CANPL3; LGMD2A; LGMDD4; LGMDR1; CAPN3

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Mouse skeletal muscle, Rat skeletal muscle, THP-1

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 70-309 of human CAPN3 (NP_775111.1).	Target Species	Human
Uniprot ID	P20807	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 70-309 of human CAPN3 (NP_775111.1).

Target Species

Human

Uniprot ID

P20807

Immunogen Sequence

Background Information

Uniprot Id

P20807
Target Species

Human
Target Name

CAPN3
Target Full Name

Calpain-3
Target Function

Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.
Target Involvement

Limb-girdle muscular dystrophy 2A (LGMD2A)
Target Subcellular Location

Cytoplasm. Nucleus, nucleolus.
Target Protein Families

Peptidase C2 family
Target Tissue Specificity

Isoform I is skeletal muscle specific.
Target Research Area

Cell Biology
Target Synonyms

Calcium-activated neutral proteinase 3; calpain 3, (p94); Calpain L3; Calpain large polypeptide L3 ; Calpain p94; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; Calpain-3; CAN3_HUMAN; CANP 3; CANP3; CANPL3; CAPN3; LGMD 2A; LGMD2; LGMD2A; Lp82; Lp85; MGC10767; MGC11121; MGC14344; MGC4403; Muscle-specific calcium-activated neutral protease 3; muscle-specific calcium-activated neutral protease 3 large subunit; nCL-1; New calpain 1; p94
Target Background

Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.

Rabbit anti-Human CAPN3 Polyclonal Antibody

Specifications

Immunogen Information

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