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The antibody against CARD14 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CARD 14. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, IF, ELISA.
The antibody against CARD14 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CARD 14. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, IF, ELISA.
$167.00
| Cat.No | ADC-33753A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CARD14 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human CARD 14. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BXL6 |
Uniprot Id
Q9BXL6
Target Species
Human
Target Name
CARD14
Target Full Name
Caspase recruitment domain-containing protein 14
Target Function
Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.; Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator.
Target Involvement
Psoriasis 2 (PSORS2); Pityriasis rubra pilaris (PRP)
Target Subcellular Location
[Isoform 1]: Cytoplasm.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.
Target Tissue Specificity
Isoform 1 is detected in placenta and epidermal keratinocytes. Isoform 2 is detected in leukocytes and fetal brain.
Target Synonyms
Bcl10 interacting MAGUK protein 2; Bimp 2; Bimp2 ; CAR14_HUMAN; CARD 14; CARD containing MAGUK 2 protein; CARD containing MAGUK protein 2; Card maguk protein 2; CARD-containing MAGUK protein 2; CARD14; Carma 2; Carma2; Caspase recruitment domain containing protein 14; Caspase recruitment domain family member 14; Caspase recruitment domain protein 14; Caspase recruitment domain-containing protein 14; PRP; PSORS2; PSS1
Target Background
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.
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