Rabbit anti-Human CARD14 Polyclonal Antibody

Uniprot Id

Q9BXL6

Target Species

Human

Target Name

CARD14

Target Full Name

Caspase recruitment domain-containing protein 14

Target Function

Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.; Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator.

Target Involvement

Psoriasis 2 (PSORS2); Pityriasis rubra pilaris (PRP)

Target Subcellular Location

[Isoform 1]: Cytoplasm.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.

Target Tissue Specificity

Isoform 1 is detected in placenta and epidermal keratinocytes. Isoform 2 is detected in leukocytes and fetal brain.

Target Synonyms

Bcl10 interacting MAGUK protein 2; Bimp 2; Bimp2 ; CAR14_HUMAN; CARD 14; CARD containing MAGUK 2 protein; CARD containing MAGUK protein 2; Card maguk protein 2; CARD-containing MAGUK protein 2; CARD14; Carma 2; Carma2; Caspase recruitment domain containing protein 14; Caspase recruitment domain family member 14; Caspase recruitment domain protein 14; Caspase recruitment domain-containing protein 14; PRP; PSORS2; PSS1

Target Background

This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.