Rabbit anti-Human CARS Monoclonal Antibody

The antibody against CARS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 650-748 of human CARS (P49589) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-14392A

Number

Cat.No	ADA-14392A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	CARS
Target Synonyms	CARS; MDBH; CYSRS; MCDDBH; MGC:11246	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, A549, MCF7, Rat pancreas, U-87MG	Application	ELISA, WB, IHC-P

Cat.No

ADA-14392A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

CARS

Target Synonyms

CARS; MDBH; CYSRS; MCDDBH; MGC:11246

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, A549, MCF7, Rat pancreas, U-87MG

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 650-748 of human CARS (P49589).	Target Species	Human
Immunogen Sequence	EREEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKELSKGQAKKLKKLFEAQEKLYKEYLQMAQNGSFQ	Uniprot ID	P49589

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 650-748 of human CARS (P49589).

Target Species

Human

Immunogen Sequence

EREEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKELSKGQAKKLKKLFEAQEKLYKEYLQMAQNGSFQ

Uniprot ID

P49589

Background Information

Uniprot Id

P49589
Target Species

Human
Target Name

CARS1
Target Full Name

Cysteine--tRNA ligase, cytoplasmic
Target Function

Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
Target Involvement

A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.
Target Subcellular Location

Cytoplasm.
Target Protein Families

Class-I aminoacyl-tRNA synthetase family
Target Synonyms

Cysteine tRNA ligase; Cars; CysRS; Cysteine--tRNA ligase; Cysteinyl tRNA synthetase, cytoplasmic; Cysteinyl-tRNA synthetase; cytoplasmic; MGC:11246; SYCC_HUMAN
Target Background

This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.

Rabbit anti-Human CARS Monoclonal Antibody

Specifications

Immunogen Information

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