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The antibody against CASTOR1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human CASTOR1 (NP_001032755.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against CASTOR1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human CASTOR1 (NP_001032755.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
Western blot analysis of various lysates, using CASTOR1 Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
| Cat.No | ADA-10630A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CASTOR1 |
| Target Synonyms | GATSL3; CASTOR1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Jurkat, Mouse lung | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human CASTOR1 (NP_001032755.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8WTX7 | Immunogen Sequence |
Uniprot Id
Q8WTX7
Target Species
Human
Target Name
CASTOR1
Target Full Name
Cytosolic arginine sensor for mTORC1 subunit 1
Target Function
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
GATS family
Target Tissue Specificity
Widely expressed.
Target Synonyms
GATL3_HUMAN; GATS-like protein 3; GATSL3
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