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The antibody against CBLIF was raised in rabbit using the Recombinant Human Cobalamin binding intrinsic factor protein (19-417AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against CBLIF was raised in rabbit using the Recombinant Human Cobalamin binding intrinsic factor protein (19-417AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using CBLIF Antibody at dilution of 1:1002
| Cat.No | ADC-43953A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CBLIF |
| Target Synonyms | CBLIF antibody; GIF antibody; IFMH antibody; Cobalamin binding intrinsic factor antibody; Gastric intrinsic factor antibody; Intrinsic factor antibody; IF antibody; INF antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cobalamin binding intrinsic factor protein (19-417AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P27352 |
Uniprot Id
P27352
Target Species
Human
Target Name
CBLIF
Target Full Name
Cobalamin binding intrinsic factor
Target Function
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.
Target Involvement
Hereditary intrinsic factor deficiency (IFD)
Target Subcellular Location
Secreted.
Target Protein Families
Eukaryotic cobalamin transport proteins family
Target Tissue Specificity
Gastric mucosa.
Target Research Area
Immunology
Target Synonyms
CBLIF; GIF; IFMH; Cobalamin binding intrinsic factor; Gastric intrinsic factor; Intrinsic factor; IF; INF
Target Background
This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia.
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