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The antibody against CBR4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human CBR4 (NP_116172.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CBR4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human CBR4 (NP_116172.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03861A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CBR4 |
| Target Synonyms | SDR45C1; CBR4 | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, Jurkat, MCF7 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human CBR4 (NP_116172.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8N4T8 | Immunogen Sequence |
Uniprot Id
Q8N4T8
Target Species
Human
Target Name
CBR4
Target Full Name
3-oxoacyl-[acyl-carrier-protein] reductase
Target Function
Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Target Tissue Specificity
Detected in liver and kidney (at protein level). Displays the highest expression in neuronal and muscle tissues.
Target Research Area
Signal Transduction
Target Synonyms
3 oxoacyl [acyl carrier protein] reductase; 3-oxoacyl-[acyl-carrier-protein] reductase; Carbonic reductase 4; Carbonyl reductase 4; Carbonyl reductase family member 4; CBR 4; Cbr4; CBR4_HUMAN; FLJ14431; Quinone reductase CBR4; SDR45C1; Short chain dehydrogenase/reductase family 45C member 1
Target Background
Enables several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Located in mitochondrial matrix. Part of oxidoreductase complex.
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