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The antibody against CBX8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 80-280 of human CBX8 (NP_065700.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against CBX8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 80-280 of human CBX8 (NP_065700.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-10710A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CBX8 |
| Target Synonyms | PC3; RC1; CBX8 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, A-549, MCF-7, Mouse thymus | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 80-280 of human CBX8 (NP_065700.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9HC52 | Immunogen Sequence |
Uniprot Id
Q9HC52
Target Species
Human
Target Name
CBX8
Target Full Name
Chromobox protein homolog 8
Target Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Target Subcellular Location
Nucleus.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Cbx8; CBX8_HUMAN; Chromobox Homolog 8 (Drosophila Pc Class); Chromobox Homolog 8 (Pc Class Homolog; Drosophila); Chromobox Homolog 8; Chromobox protein homolog 8; hPc3; Pc Class 3 Homolog (Drosophila); Pc Class 3 Homolog; Pc3; Polycomb 3; Polycomb 3 homolog; RC1; Rectachrome 1
Target Background
Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma.
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