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The antibody against CBX8 was raised in rabbit using the Recombinant Human Chromobox protein homolog 8 protein (80-280AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against CBX8 was raised in rabbit using the Recombinant Human Chromobox protein homolog 8 protein (80-280AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human skin tissue using CBX8 Antibody at dilution of 1:1002
| Cat.No | ADC-45063A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CBX8 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Chromobox protein homolog 8 protein (80-280AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HC52 |
Uniprot Id
Q9HC52
Target Species
Human
Target Name
CBX8
Target Full Name
Chromobox protein homolog 8
Target Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Target Subcellular Location
Nucleus.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Cbx8; CBX8_HUMAN; Chromobox Homolog 8 (Drosophila Pc Class); Chromobox Homolog 8 (Pc Class Homolog; Drosophila); Chromobox Homolog 8; Chromobox protein homolog 8; hPc3; Pc Class 3 Homolog (Drosophila); Pc Class 3 Homolog; Pc3; Polycomb 3; Polycomb 3 homolog; RC1; Rectachrome 1
Target Background
Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma.
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