Rabbit anti-Human CCDC22 Polyclonal Antibody

Uniprot Id

O60826

Target Species

Human

Target Name

CCDC22

Target Full Name

Coiled-coil domain-containing protein 22

Target Function

Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.; (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.

Target Involvement

Ritscher-Schinzel syndrome 2 (RTSC2)

Target Subcellular Location

Endosome.

Target Protein Families

CCDC22 family

Target Tissue Specificity

Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle.

Target Synonyms

AI481216; CCD22_HUMAN; Ccdc22; chromosome X open reading frame 37; Coiled-coil domain-containing protein 22; CXorf37; DXImx40e; JM1; RGD1560910; Sfc22