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The antibody against CD11a was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 26-340 of human CD11a (NP_002200.2?) as the immunogen. The monoclonal antibody exists as a isotype IgG1, by affinity purification. This antibody has been validated on WB, FC.
The antibody against CD11a was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 26-340 of human CD11a (NP_002200.2?) as the immunogen. The monoclonal antibody exists as a isotype IgG1, by affinity purification. This antibody has been validated on WB, FC.
Western blot analysis of lysates from MOLT-4 cells using CD11a Rabbit mAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
| Cat.No | ADA-15602A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CD11a |
| Target Synonyms | CD11A; LFA-1; LFA1A; CD11a | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG1 |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Molt-4 | Application | WB, FC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 26-340 of human CD11a (NP_002200.2) | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P20701 | Immunogen Sequence |
Uniprot Id
P20701
Target Species
Human
Target Name
ITGAL
Target Full Name
Integrin alpha-L
Target Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Integrin alpha chain family
Target Tissue Specificity
Leukocytes.
Target Research Area
Immunology
Target Synonyms
Antigen CD11A (p180); lymphocyte function associated antigen 1; alpha polypeptide; CD11 antigen-like family member A; CD11a; CD18; CR3; Integrin alpha-L; Integrin beta 2 ; Integrin gene promoter; ITAL_HUMAN; Itgal; ITGAM; ITGB2; LAD; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA 1 alpha; LFA 1; LFA-1A; LFA1; LFA1A; Lymphocyte function associated antigen 1; MAC1; MFI7; MO1A
Target Background
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
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