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The antibody against CD138/Syndecan-1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human CD138/Syndecan-1 (NP_002988.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against CD138/Syndecan-1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human CD138/Syndecan-1 (NP_002988.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
Western blot analysis of various lysates, using CD138/Syndecan-1 Rabbit pAb at 1:500 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
| Cat.No | ADA-11762A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CD138/Syndecan-1 |
| Target Synonyms | SDC; CD138; SYND1; syndecan; CD138/Syndecan-1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, U266 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human CD138/Syndecan-1 (NP_002988.4). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P18827 | Immunogen Sequence |
Uniprot Id
P18827
Target Species
Human
Target Name
SDC1
Target Full Name
Syndecan-1
Target Function
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Target Subcellular Location
Membrane; Single-pass type I membrane protein. Secreted. Secreted, extracellular exosome.
Target Protein Families
Syndecan proteoglycan family
Target Research Area
Cancer
Target Synonyms
CD_antigen; CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; SDC; Sdc1; SDC1_HUMAN; SYND1; Syndecan 1; Syndecan; syndecan proteoglycan 1; Syndecan-1
Target Background
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
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