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The antibody against CD180 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human CD180 (NP_005573.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CD180 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human CD180 (NP_005573.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06464A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CD180 |
| Target Synonyms | LY64; Ly78; RP105; CD180 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, LO2, Raji, THP-1 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human CD180 (NP_005573.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | WDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFD | Uniprot ID | Q99467 |
Uniprot Id
Q99467
Target Species
Human
Target Name
CD180
Target Full Name
CD180 antigen
Target Function
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Toll-like receptor family
Target Tissue Specificity
Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
Target Synonyms
CD180; CD180 antigen; CD180_HUMAN; F630107B15; LY64; Ly78; Lymphocyte antigen 64; lymphocyte antigen 64 radioprotective 105kDa; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; Radioprotective 105 kDa protein; RP105
Target Background
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.
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