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The antibody against CD27 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-191 of human CD27 (NP_001233.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against CD27 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-191 of human CD27 (NP_001233.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-04449A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CD27 |
| Target Synonyms | T14; S152; Tp55; TNFRSF7; S152. LPFS2; CD27 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse spleen, Mouse thymus, Raji, Rat lung | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 20-191 of human CD27 (NP_001233.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | ATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSDFIR | Uniprot ID | P26842 |
Uniprot Id
P26842
Target Species
Human
Target Name
CD27
Target Full Name
CD27 antigen
Target Function
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Target Involvement
Lymphoproliferative syndrome 2 (LPFS2)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Found in most T-lymphocytes.
Target Synonyms
CD27; TNFRSF7; CD27 antigen; CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD antigen CD27
Target Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
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