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The antibody against CD89 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 22-227 of human CD89 (NP_001991.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, FC, ELISA.
The antibody against CD89 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 22-227 of human CD89 (NP_001991.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, FC, ELISA.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with CD89 using CD89 Rabbit mAb at 1:1500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 60s.
| Cat.No | ADA-15193A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CD89 |
| Target Synonyms | CD89; FcalphaR; FcalphaRI; CTB-61M7.2; FCAR | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T transfected with CD89 (Human) | Application | ELISA, WB, FC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 22-227 of human CD89 (NP_001991.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P24071 | Immunogen Sequence |
Uniprot Id
P24071
Target Species
Human
Target Name
FCAR
Target Full Name
Immunoglobulin alpha Fc receptor
Target Function
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Target Subcellular Location
[Isoform A.1]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.2]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.3]: Cell membrane; Single-pass type I membrane protein.; [Isoform B]: Secreted.; [Isoform B-delta-S2]: Secreted.
Target Tissue Specificity
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however
Target Synonyms
FCAR; CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD antigen CD89
Target Background
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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