Rabbit anti-Human CDC5L Monoclonal Antibody

The antibody against CDC5L was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 300-400 of human CDC5L (Q99459) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-16142A

Number

Cat.No	ADA-16142A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	CDC5L
Target Synonyms	CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1; CDC5L	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, Mouse brain, Mouse testis, Mouse thymus, SH-SY5Y	Application	ELISA, WB, IHC-P

Cat.No

ADA-16142A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

CDC5L

Target Synonyms

CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1; CDC5L

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, Mouse brain, Mouse testis, Mouse thymus, SH-SY5Y

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 300-400 of human CDC5L (Q99459).	Target Species	Human
Immunogen Sequence	PQISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQ	Uniprot ID	Q99459

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 300-400 of human CDC5L (Q99459).

Target Species

Human

Immunogen Sequence

PQISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQ

Uniprot ID

Q99459

Background Information

Uniprot Id

Q99459
Target Species

Human
Target Name

CDC5L
Target Full Name

Cell division cycle 5-like protein
Target Function

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
Target Involvement

A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.
Target Subcellular Location

Nucleus. Nucleus speckle. Cytoplasm.
Target Protein Families

CEF1 family
Target Tissue Specificity

Ubiquitously expressed in both fetal and adult tissues.
Target Synonyms

CDC5; CDC5 cell division cycle 5-like (S. pombe); Cdc5 related protein; CDC5-LIKE; Cdc5-like protein; Cdc5l; CDC5L_HUMAN; CEF1; Cell division cycle 5 S. pombe homolog of; Cell division cycle 5-like protein; dJ319D22.1; KIAA0432; PCDC5RP; Pombe Cdc5 related protein; Pombe Cdc5-related protein
Target Background

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.

Rabbit anti-Human CDC5L Monoclonal Antibody

Specifications

Immunogen Information

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