Rabbit anti-Human CDC5L Polyclonal Antibody

The antibody against CDC5L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 563-802 of human CDC5L (NP_001244.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11194A

Number

Cat.No	ADA-11194A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CDC5L
Target Synonyms	CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1; CDC5L	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	K-562, MCF7, Mouse spleen, Mouse testis, Mouse thymus, SW480, THP-1	Application	ELISA, WB

Cat.No

ADA-11194A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CDC5L

Target Synonyms

CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1; CDC5L

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

K-562, MCF7, Mouse spleen, Mouse testis, Mouse thymus, SW480, THP-1

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 563-802 of human CDC5L (NP_001244.1).	Target Species	Human
Uniprot ID	Q99459	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 563-802 of human CDC5L (NP_001244.1).

Target Species

Human

Uniprot ID

Q99459

Immunogen Sequence

Background Information

Uniprot Id

Q99459
Target Species

Human
Target Name

CDC5L
Target Full Name

Cell division cycle 5-like protein
Target Function

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
Target Involvement

A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.
Target Subcellular Location

Nucleus. Nucleus speckle. Cytoplasm.
Target Protein Families

CEF1 family
Target Tissue Specificity

Ubiquitously expressed in both fetal and adult tissues.
Target Synonyms

CDC5; CDC5 cell division cycle 5-like (S. pombe); Cdc5 related protein; CDC5-LIKE; Cdc5-like protein; Cdc5l; CDC5L_HUMAN; CEF1; Cell division cycle 5 S. pombe homolog of; Cell division cycle 5-like protein; dJ319D22.1; KIAA0432; PCDC5RP; Pombe Cdc5 related protein; Pombe Cdc5-related protein
Target Background

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.

Rabbit anti-Human CDC5L Polyclonal Antibody

Specifications

Immunogen Information

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