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The antibody against CDCA7L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CDCA7L (NP_061189.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CDCA7L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CDCA7L (NP_061189.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05034A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CDCA7L |
| Target Synonyms | R1; JPO2; RAM2; CDCA7L | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, A-549, Jurkat, Mouse brain, Mouse spleen | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CDCA7L (NP_061189.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96GN5 | Immunogen Sequence |
Uniprot Id
Q96GN5
Target Species
Human
Target Name
CDCA7L
Target Full Name
Cell division cycle-associated 7-like protein
Target Function
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Target Subcellular Location
Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
Target Tissue Specificity
Ubiquitous. Overexpressed in medulloblastoma.
Target Synonyms
c Myc Interacting protein JPO2; CDA7L_HUMAN; Cdca7l; Cell division cycle-associated 7-like protein; DKFZp762L0311; HR1; JPO2; Protein JPO2; R1; RAM2; Transcription factor RAM2
Target Background
Acts upstream of or within positive regulation of cell population proliferation. Located in cytosol; fibrillar center; and nucleoplasm.
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