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The antibody against CDCA7L was raised in rabbit using the Recombinant Human Cell division cycle-associated 7-like protein (14-167AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against CDCA7L was raised in rabbit using the Recombinant Human Cell division cycle-associated 7-like protein (14-167AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-05511A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CDCA7L |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cell division cycle-associated 7-like protein (14-167AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96GN5 |
Uniprot Id
Q96GN5
Target Species
Human
Target Name
CDCA7L
Target Full Name
Cell division cycle-associated 7-like protein
Target Function
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Target Subcellular Location
Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
Target Tissue Specificity
Ubiquitous. Overexpressed in medulloblastoma.
Target Synonyms
c Myc Interacting protein JPO2; CDA7L_HUMAN; Cdca7l; Cell division cycle-associated 7-like protein; DKFZp762L0311; HR1; JPO2; Protein JPO2; R1; RAM2; Transcription factor RAM2
Target Background
Acts upstream of or within positive regulation of cell population proliferation. Located in cytosol; fibrillar center; and nucleoplasm.
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