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The antibody against CDKAL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CDKAL1 (NP_060244.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against CDKAL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CDKAL1 (NP_060244.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-03677A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CDKAL1 |
| Target Synonyms | CDKAL1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Mouse kidney, 293T, BT-474, HepG2, HL-60, Mouse lung, Mouse spleen | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CDKAL1 (NP_060244.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q5VV42 | Immunogen Sequence |
Uniprot Id
Q5VV42
Target Species
Human
Target Name
CDKAL1
Target Full Name
Threonylcarbamoyladenosine tRNA methylthiotransferase
Target Function
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Target Involvement
Diabetes mellitus, non-insulin-dependent (NIDDM)
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein.
Target Protein Families
Methylthiotransferase family, CDKAL1 subfamily
Target Tissue Specificity
Expressed in pancreatic islets.
Target Synonyms
CDKAL1; Threonylcarbamoyladenosine tRNA methylthiotransferase; CDK5 regulatory subunit-associated protein 1-like 1; tRNA-t(6A37 methylthiotransferase
Target Background
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes.
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