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The antibody against CDSN was raised in rabbit using the Recombinant Human Corneodesmosin protein (40-229AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against CDSN was raised in rabbit using the Recombinant Human Corneodesmosin protein (40-229AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human lymph node tissue using CDSN Antibody at dilution of 1:100
| Cat.No | ADC-16100A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CDSN |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Corneodesmosin protein (40-229AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15517 |
Uniprot Id
Q15517
Target Species
Human
Target Name
CDSN
Target Full Name
Corneodesmosin
Target Function
Important for the epidermal barrier integrity.
Target Involvement
Hypotrichosis 2 (HYPT2); Peeling skin syndrome 1 (PSS1)
Target Subcellular Location
Secreted. Note=Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
Target Tissue Specificity
Exclusively expressed in skin.
Target Synonyms
AI747712; CDSN; CDSN_HUMAN; Corneodesmosin; D6S586E; DADB-141O4.5; Differentiated keratinocyte S protein; HTSS; S; S protein
Target Background
This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.
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