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The antibody against CEL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 350-550 of human CEL (NP_001798.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CEL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 350-550 of human CEL (NP_001798.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03373A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CEL |
| Target Synonyms | BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8; CEL | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse pancreas | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 350-550 of human CEL (NP_001798.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P19835 | Immunogen Sequence |
Uniprot Id
P19835
Target Species
Human
Target Name
CEL
Target Full Name
Bile salt-activated lipase
Target Function
Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins.
Target Involvement
Maturity-onset diabetes of the young 8 with exocrine dysfunction (MODY8)
Target Subcellular Location
Secreted.
Target Protein Families
Type-B carboxylesterase/lipase family
Target Tissue Specificity
Mammary gland and pancreas. Detected in pancreatic and duodenal juice (at protein level). Expressed by eosinophils.
Target Synonyms
CEL; BALBile salt-activated lipase; BAL; EC 3.1.1.13; EC 3.1.1.3; EC 3.1.1.6; Bile salt-stimulated lipase; BSSL; Bucelipase; Carboxyl ester lipase; Cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase
Target Background
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein.
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