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The antibody against CENPQ was raised in rabbit using the Recombinant Human Centromere protein Q protein (131-268AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against CENPQ was raised in rabbit using the Recombinant Human Centromere protein Q protein (131-268AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human liver cancer using CENPQ Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CENPQ Antibody at dilution of 1:1002
| Cat.No | ADC-40297A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CENPQ |
| Target Synonyms | CENP Q antibody; CENP-Q antibody; Cenpq antibody; CENPQ_HUMAN antibody; Centromere protein Q antibody; FLJ10545 antibody; OTTHUMP00000016579 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Centromere protein Q protein (131-268AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7L2Z9 |
Uniprot Id
Q7L2Z9
Target Species
Human
Target Name
CENPQ
Target Full Name
Centromere protein Q
Target Function
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores.
Target Subcellular Location
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Target Protein Families
CENP-Q/OKP1 family
Target Synonyms
CENP Q; CENP-Q; Cenpq; CENPQ_HUMAN; Centromere protein Q; FLJ10545; OTTHUMP00000016579
Target Background
CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).
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