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The antibody against CEP164 was raised in rabbit using the Recombinant Human Centrosomal protein of 164 kDa protein (1-112AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against CEP164 was raised in rabbit using the Recombinant Human Centrosomal protein of 164 kDa protein (1-112AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-03096A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CEP164 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Centrosomal protein of 164 kDa protein (1-112AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UPV0 |
Uniprot Id
Q9UPV0
Target Species
Human
Target Name
CEP164
Target Full Name
Centrosomal protein of 164 kDa
Target Function
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Target Involvement
Nephronophthisis 15 (NPHP15)
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Target Tissue Specificity
Expressed in several cell lines.
Target Synonyms
AI450905; BC027092; CE164_HUMAN; Centrosomal protein 164; Centrosomal protein 164kDa; Centrosomal protein of 164 kDa; Cep164; D030051D21; FLJ54767; KIAA1052; MGC38792; mKIAA1052; NPHP15; OTTMUSP00000042044; RGD1560988; RGD1561243
Target Background
This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene.
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