Rabbit anti-Human Ceruloplasmin Polyclonal Antibody

Uniprot Id

P00450

Target Species

Human

Target Name

CP

Target Full Name

Ceruloplasmin

Target Function

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense.

Target Involvement

Aceruloplasminemia (ACERULOP)

Target Subcellular Location

Secreted.

Target Protein Families

Multicopper oxidase family

Target Tissue Specificity

Expressed by the liver and secreted in plasma.

Target Research Area

Signal Transduction

Target Synonyms

CERU_HUMAN; Ceruloplasmin; CP 2; CP; CP2; Ferroxidase

Target Background

The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.